I've gotten a few copyright law questions, and I figured I'd try to answer them all at once. Let me first get the required stuff out of the way...
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Whew! Now on to the questions....
Should I register my book with the copyright office before submitting to agents or publishers?
Registering your book is always the safest and wisest course of action (especially if you're submitting to a packager), and so I would never encourage you not to do so. Still, you should know that copyright in the work automatically vests at the time of creation, and not registration (assuming that your book is an original work of authorship). Also, it's very likely that you'll revise your work significantly between the time of initial writing and its final publication, and you and or your publisher will need to register the revised book as well.
Do I have to put a copyright notice on my book before submitting?
Notice is no longer a requirement, though you can include it if you've registered your work.
Will my publisher register my book with the copyright office?
Most contracts require the publisher to register the book. This isn't enough though - your publisher should actually be required to register the book within three months of publication. Registration within three months allows you to become eligible to receive statutory damages and legal costs and attorneys' fees from a copyright infringer.
Sadly, publishers are now trying to duck out of this requirement by adding language that states that they don't have to register your book "if, prior to the time of publication, U.S. copyright law is amended so that registration is no longer a prerequisite to the recovery of attorneys' fees and statutory damages."
This is short-sighted and you or your agent should try to fight this. It fails to take into account lots of other benefits that come with registration, like providing a public record of your copyright claim or that copyright registration is a prerequisite to bringing a copyright infringement suit. Sure, you can register your copyright later and then sue, but you'll end up paying a lot more to expedite the process since you'll want to immediately obtain an injunction against whoever is infringing your copyright.
I should tell you that despite the overwhelming evidence that this language bites for both author and publisher, so far some publishers have been unwilling to change it.
I've got an awesome title for my book. Is it copyrightable?
Typically not. And it probably isn't that awesome.